Taken together, these data point toward an autocrine mechanism mediated by TYK2 in which ALCL cells produce IL-10 and IL-22, which bind to their receptors on the same cells, activating an autocrine TYK2-mediated single transduction pathway resulting in pYSTAT1 with efficient translocation and gene regulation in the nucleus, where it is essential for survival of the cells and autonomous cell growth. Here, IL22 is linked to anaplastic large cell lymphoma.