Bayer-18 also had minimal activity against PBMCs and had comparable activity to TYK2#1 in ALK- ALCL but was less active in ALK+ ALCL cell lines (ALK- 70.1 ± 2.1% versus ALK+ 20.6 ± 5.6% reduction in viability; Fig. 3b, Suppl. The gene discussed is ALK; the disease is anaplastic large cell lymphoma.