TYK2 and anaplastic large cell lymphoma: Taken together, these data point toward an autocrine mechanism mediated by TYK2 in which ALCL cells produce IL-10 and IL-22, which bind to their receptors on the same cells, activating an autocrine TYK2-mediated single transduction pathway resulting in pYSTAT1 with efficient translocation and gene regulation in the nucleus, where it is essential for survival of the cells and autonomous cell growth.