JAK1 and anaplastic large cell lymphoma: Thus, both IL-10 and IL-22 are expressed by ALCL cells and form autocrine loops to activate TYK2, which along with its heterodimeric partner JAK1 provides the signaling component of both the IL-10 receptor (IL10RA/IL10RB) and the IL-22 receptor (IL10RA/IL22RA) [47].