TYK2 and anaplastic large cell lymphoma: TYK2 mRNA levels were analyzed using RNA isolated from formalin fixed paraffin embedded (FFPE) ALCL patient samples (7 ALCL, ALK+, 4 ALCL, ALK-, and 8 reactive lymph nodes (LN)) showing an upregulation across all ALCL samples (ALK neg: 7.1 ± 2.5, ALK pos: 7.7 ± 3.4, reactive LN 1.0 ± 0.4) as compared to lymph nodes from healthy donors (P = 0.0289) (Fig. 6a).