ALK and anaplastic large cell lymphoma: Remarkably, loss of TYK2 through a STOP codon in the FERM domain (TYK2-CRISPR1) resulted in severe growth retardation indicative of TYK2 dependency in two different ALCL cell lines representing NPM-ALK-positive (SR786) and ALK-negative (Mac1, ALK−) lines (Fig. 2a).