For example, increased expression of serum IL-6 has been found to effectively discriminate patients with TSCC from controls with an excellent sensitivity.23 Likewise, in another study, elevated salivary levels of IL-6 and IL-8 were reported to reliably and accurately identify the progression of TSCC from high-risk to neoplasm.31 This implies increased usefulness of combining these two markers in early detection of new or recurrent cases of TSCC. The gene discussed is CXCL8; the disease is neoplasm.