Genome-wide analysis of DNA methylation in whole blood from a sample of schizophrenia patients (N = 74) and controls (N = 79), where one-third of both groups were exposed in utero to the great famine in China (1959–1961), identified one region in the promoter of the dual specificity phosphatase 22 (DUSP22) gene (Chr6:291687-293285) with significantly higher DNA methylation levels in famine-exposed schizophrenia patients compared to unexposed patients and healthy controls. The gene discussed is DUSP22; the disease is schizophrenia.