Specifically, Unick et al. [64] demonstrated that GLP-1 concentrations were lower 1 h after a single bout of moderate-intensity walking in women with overweight/obese (BMI 25.0–34.9 kg∙m−2), yet Holliday and Blannin [61] showed recently that GLP-1 was elevated 1 h after low-volume sprint interval cycling in individuals with overweight or obesity (BMI 25.0–34.9 kg∙m−2). The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.