With regard to appetite hormones, Douglas et al. [33] reported that exercise-induced changes in total PYY and GLP-1 may be modulated by adiposity status, with the group with overweightness/obesity exhibiting a greater elevation in total GLP-1 after exercise, whereas the group that were lean demonstrated a greater exercise-induced increase in total PYY. This evidence concerns the gene GCG and obesity due to melanocortin 4 receptor deficiency.