This is well illustrated by Gibbons and colleagues who demonstrated recently that individuals with overweightness and obesity who lost more weight after a 12 week aerobic exercise intervention displayed an elevated postprandial rise in GLP-1 and total PYY, and a greater suppression in acylated ghrelin compared to those who lost less weight [73]. Here, GHRL is linked to obesity due to melanocortin 4 receptor deficiency.