This was seen in our in vivo studies using the jugular vein catheter mouse model where overexpression of PES1 in biofilms growing in the lumen of the catheters resulted in enhanced dispersal and disseminated infection, while repression of PES1 resulted in abrogation of biofilm dispersal and a 15-fold decrease in Candida infection of distal organs. The gene discussed is PES1; the disease is candidiasis.