This study investigated the relationship between leptin and ghrelin in PCOS-affected Saudi women and showed that leptin is probably associated with lipidograms (particularly with chol-LDL) in PCOS patients, as expected, but that the difference in serum adipokines levels between lean and obese female with PCOS, is no more significant, most probably due to an interference of insulin level and HOMA indexes [50–58]. This evidence concerns the gene GHRL and polycystic ovary syndrome.