In particular, we show that miR-548k regulates different hallmarks of cancer, including cell proliferation, migration, invasion, and tumor microenvironment remodeling through combinatorial regulating of multiple oncogenic routes, involving the ADAMTS1-VEGFC-VEGFR3 pathway and KLF10-EGFR axis (Fig. 8). The gene discussed is ADAMTS1; the disease is neoplasm.