FMR in our cases was able to discriminate PCOS secondary to FPLD2 (1.7 ± 0.2, mean± SD) from the forms of PCOS associated with severe IR without any identified genetic cause (1.3 ± 0.1, mean± SD) and from controls (0.93 ± 0.10, mean± SD), whereas neither hypertriglyceridemia nor low adiponectin or leptin circulating levels had a high diagnostic accuracy (unpublished data). Here, LEP is linked to polycystic ovary syndrome.