PIK3C2A and dilated cardiomyopathy: From the clinical point of view, the pattern of dilated cardiomyopathy related to the LMNA gene does not present unique characteristics able to clearly differentiate it from dilated cardiomyopathy related to other genes or dilated cardiomyopathy of non-genetic origin, although the finding of muscular involvement (even if CPK is elevated in only one third of cases), atrio-ventricular blocks and atrial fibrillation or atrial flutter are considered as ‘red flags’ predicting a much higher chance of a lamin A/C mutation [46–48].