Importantly, the top 5 up-regulated genes link to cancer or immunomodulation, including calpain 11 (Capn11), immunoglobulin kappa chain variable 5–43 (Igkv5-43), immunoglobulin heavy constant alpha (Igha), immunoglobulin heavy variable 1–26 (Ighv1-26), and immunoglobulin heavy constant gamma 2B (Ighg2b) [29–33]. Here, CAPN11 is linked to cancer.