Additional studies by this group also reported the detection of ctDNA mutations to NRAS prior to disease progression while on anti-EGFR therapy, and showed using a mouse xenotransplant model that tumor from a colorectal cancer patient who had initially responded and then relapsed while on anti-EGFR therapy significantly responded to combination treatment with both anti-EGFR and anti-MEK inhibition (59). Here, EGFR is linked to neoplasm.