siRNA knockdown of DGKA or inhibition of DGKα by small molecule inhibitors for DGKs, R59022 and R59949, has detrimental effects on the proliferation of glioblastoma cells, melanoma, breast cancer, and cervical cancer cells (Yanagisawa et al., 2007; Dominguez et al., 2013). Here, DGKA is linked to melanoma.