Diacylglycerol kinases are a family of multi-domain lipid kinase that regulate a variety of cellular process (Sakane et al., 2007; Merida, Ávila-Flores & Merino, 2008; Shulga, Topham & Epand, 2011), and DGKα has recently emerged as a novel therapeutic target for cancer immunotherapy (Dominguez et al., 2013; Purow, 2015; Sakane, Mizuno & Komenoi, 2016; Liu et al., 2016; Noessner, 2017). The gene discussed is DGKA; the disease is cancer.