siRNA knockdown of DGKA or inhibition of DGKα by small molecule inhibitors for DGKs, R59022 and R59949, has detrimental effects on the proliferation of glioblastoma cells, melanoma, breast cancer, and cervical cancer cells (Yanagisawa et al., 2007; Dominguez et al., 2013). This evidence concerns the gene DGKA and breast cancer.