As GADD45A plays a role in genomic stability and tumorigenesis, some studies explored the role of GADD45A in various cancers, such as prostate cancer (Reis et al., 2015), ovarian cancer (Yuan et al., 2015), esophageal cancer (Ishiguro et al., 2016) and malignant gliomas (Cui et al., 2017), which revealed different GADD45A expressions in various carcinoma tissues. The gene discussed is GADD45A; the disease is esophageal cancer.