GADD45A and neoplasm: Beyond that, a study showed that GADD45A promotes Myc-driven breast carcinogenesis by negatively regulating matrix metalloproteinase 10 (MMP10) through GSK-3β (Glycogen synthase kinase 3 beta)/β-catenin signaling, resulting in increased tumor vascularization and growth (Tront et al., 2010).