Furthermore, umbelliprenin treatment in animal model of colorectal cancer showed reduction of tumor size, angiogenesis (showed by VEGF, MMP2, MMP9, and CD31 reduction and E-cadherin increment), proliferation (showed by KI-67 marker), and metastasis (showed by MMP2, MMP9 reduction and also no signs of liver, lung, and kidney metastasis). The gene discussed is VEGFA; the disease is neoplasm.