SERPING1 and hereditary angioedema: In the UK, intravenously administered plasma-derived C1-INH (Berinert®, Cinryze®), recombinant C1-INH (Ruconest®) and the subcutaneously administered bradykinin receptor antagonist icatibant (Firazyr®) are licensed and effective for the treatment of acute attacks of HAE and are now commissioned nationally for home-based self-administration [10–15].