For example, CARD9 deficiency has been associated with an over-representation of fungi within the microbiota (56), and there have been reports of CARD9-deficient patients developing colitis caused by invasive intestinal infection with Candida glabrata (48), and most recently by the β-glucan-containing microalgae Prototheca zopfii (57). This evidence concerns the gene CARD9 and digestive system infectious disorder.