Inasmuch as the present study is a cross section of patients with long-standing disease (disease duration up to 15 years) that have a treatment history with various medications, the dominance of IL-6, IL-10, IL-17A, IFNγ, and TNFα in SF suggests a common cytokine signature of JIA synovitis. This evidence concerns the gene IL10 and juvenile idiopathic arthritis.