EGFR and cancer: Although the overexpression of the EGFR gene has also been reported in a variety of other cancers including those of head and neck, ovary, cervix, bladder, esophagus, stomach, brain, breast, endometrium, and colon (24), the above-mentioned mechanisms cannot explain the opposite results obtained via the bioinformatics analysis of Kaplan–Mayer dataset for gastric, ovarian, and breast carcinomas, where SP-D showed an unfavorable prognostic effect.