Some of the pathways include Glutathione metabolic pathway, AKT signaling, EGFR signaling, response to hypoxia and oxidative stress, Cell cycle regulation, etc. are known to play a critical role in antioxidant defense, detoxification mechanisms, cell survival, proliferation, oncogenesis and NSCLC progression (Wagner and Schmidt, 2011; Guo et al., 2015). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.