In Baizhu, 39 target proteins are identified for 17 active components with 112 interactions, including MAOA, MAOB, NOS1-3, TACR1, SLC6A4, STAT3, etc. Interestingly, majority of them are related to mental disorders and inflammation, which are confirmed associated with the pathogenesis of FD and that may be a potential therapeutic mechanism of Baizhu on FD. Here, STAT3 is linked to mental disorder.