MAPK3 and major depressive disorder: For instance, many investigations suggest that the regulation of cytosolic calcium ion concentration has an important role in anti-depression treatment (Yamawaki et al., 2001), and the abnormalities of ERK1/2 signaling may be crucial for the vulnerability of depression (Dwivedi and Zhang, 2016), moreover, the ERK activity constitutively or transiently may serve as a negative regulator of vascular inflammation by suppressing endothelial NF-κB activation, and play an anti-inflammatory role (Maeng et al., 2006).