COMT and Anxiety: Next, in accordance with the warrior-worrier hypotheses mentioned above (Goldman et al., 2005) and as the Met allele has also been associated with anxiety and related traits previously (e.g., Olsson et al., 2005; Stein et al., 2005; Hashimoto et al., 2007; Lee and Prescott, 2014), we shortly wanted to test post-hoc whether neuroticism (as an indicator of emotional instability) would mediate the effects of the Met allele of the COMT Val158Met polymorphism on Avoidance Motivation.