Next, in accordance with the warrior-worrier hypotheses mentioned above (Goldman et al., 2005) and as the Met allele has also been associated with anxiety and related traits previously (e.g., Olsson et al., 2005; Stein et al., 2005; Hashimoto et al., 2007; Lee and Prescott, 2014), we shortly wanted to test post-hoc whether neuroticism (as an indicator of emotional instability) would mediate the effects of the Met allele of the COMT Val158Met polymorphism on Avoidance Motivation. Here, COMT is linked to Emotional lability.