CX3CL1 and Parkinson disease: Several laboratories have investigated a-syn toxicity in the viral vector PD based model in several knock-out lines and suggested protective roles for fractalkine (Thome et al., 2015), highlighted the key inflammatory role of the microRNA155 (Thome et al., 2016) and the role of TLR2 in a-syn toxicity (Kim et al., 2013).