The vasodilatory peptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP-38), as well as the neurotransmitter nitric oxide (NO), are all potent vasodilators implicated in migraine pathophysiology (Brain et al., 1985; Moncada et al., 1991; Messlinger et al., 2012; Kaiser and Russo, 2013; Russo, 2015, 2017; Jansen-Olesen and Hougaard Pedersen, 2018). The gene discussed is ADCYAP1; the disease is migraine disorder.