LDB1 and retinal detachment: The Six3-Cre line offers the advantage for us to evaluate the whole-range of retinal defects resulting from Ldb1 inactivation such as optic nerve hypoplasia and retinal detachment which were unseen in the prior study; (3) We investigated the profound visual function loss in adult Ldb1 null mice by ERG, an advantage afforded by the Six3-Cre line, which was untouched in the previous work; (4) We demonstrated by a gain-of-function approach the sufficiency of Ldb1 in promoting the differentiation of all non-photoreceptor cell types at the cost of photoreceptors.