CREB1 and major depressive disorder: Chronic unpredictable mild stress (CUMS) triggers a rise in miR-182 levels at the hippocampus in rats and its overexpression exacerbates stress-induced depression-like behavior, a modification associated with a reduction in the levels of BDNF and cAMP responsive element binding protein 1 (CREB1) transcription factor (Li et al., 2016).