HSPG2 and rheumatoid arthritis: Target analysis for miR-485 revealed a large number of genes associated with canonical pathways related to Axonal Guidance Signaling (i.e., similarly to miR-92a), Huntington’s Disease Signaling, Molecular Mechanism of Cancer, Ephrin Receptor signaling, Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis; Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis, Role of NFATs in Cardiac Hypertrophy, PLC Signaling, CREB Signaling in Neurons and Role of homeobox protein NANOG in Mammalian Embryonic Stem Cell Pluripotency (Figure 10B).