EGFR and neoplasm: Our data suggest that Fas in its phosphorylated pro-survival form is an essential signaling hub for the formation of a Fas/EGFR/STAT3 complex, which promotes the activation of the non-canonical signaling pathway of EGFR and STAT3, and thus the transmission of the growth factor signals directly from the plasma membrane to the tumor-promoting transcriptional targets in the nucleus via EGFR and STAT3 nuclear transport (Summarized in Fig. 8).