We found that initial tumour growth rates were comparable between Scram and shRNA cells across all three cell lines (Fig. 5d, h and l and Supplementary Fig. 13a–c) However, upon the addition of doxycycline tumours from tumours formed by the SETD8-KD cells slowed down significantly (Fig. 5d, h, and l). Here, KMT5A is linked to neoplasm.