SKIL and non-small cell lung carcinoma: To further assess the importance of these three factors we first analysed the expression of SETD8, SKIL and TBX2 in multiple NSCLC cell lines and found that SETD8 and SKIL expression was significantly higher in LUSC cell lines (n = 5) compared to LUAD cell lines (n = 6) (Fig. 4a, b) which was in correlation with the expression levels of BCL11A and SOX2 (Fig. 4d, e).