STAT3 and non-small cell lung carcinoma: Prompted by the punctate lysosome-like pattern of RFP-STAT3 in live A549 non-small cell lung cancer cells, in which the NH2 terminus of the endogenous STAT3 gene is tagged with a red fluorescent protein (RFP) using transcription activator-like effector nuclease-mediated knock-in,34 we investigated the putative lysosomal localization and function of STAT3.