DRD2 and schizophrenia: The methods of treatment of schizophrenia are classified as the first (mainly dopamine D2 receptor antagonists), second (multi-target antagonists with greater antagonism at serotonin 5-HT2A receptor than at dopamine D2 receptor) and third generation antipsychotics represented, e.g., by aripiprazole, brexpiprazole and cariprazine.