AKT1 and hepatocellular carcinoma: The antimetastatic effect of bufalin was studied in human hepatocellular carcinoma SK-Hep1 cells to determine if bufalin plays an important role in mortality of cancer patients, in which the expression of matrix metalloproteinases (MMPs), such as MMP-2 and -9 are inhibited, while phosphoinisitide-3-kinase (PI3K) and phosphorylation of AKT are reduced with the suppression of NF-κB [46].