PTGS2 and non-small cell lung carcinoma: A study has shown gamabufotalin strongly suppressed COX-2 expression by inhibiting the phosphorylation of IKKβ via targeting the ATP-binding site, which in turn, prevents NF-κB binding and p300 recruitment to COX-2 promoter in a range of human NSCLC, H1299, A549, H322, and H460 cell lines.