PTGS2 and cancer: pUS28 activates a variety of signaling cascades that can function to promote cancer, including PLC [55], cyclooxygenase 2 (COX2) via NFκB [70,72], Wnt [75], hypoxia-inducible factor 1α (HIF1α) [76], and the STAT3-interleukin 6 (IL6) axis [73,74].