EMB and infection: With the production of the monoclonal antibody IgG1 against Gp70 (mAb P6E7) it was demonstrated that a protective response against experimental sporotrichosis could be established as shown in Figure 1, since mice passively immunized with the antibody (before, during, and after infection) had a significant reduction of fungal load in the spleen and liver, and it did not develop more severe forms of the disease [63,66,70].