CTNNB1 and neoplasm: Recent studies demonstrated that TCS can inhibit tumor cell proliferation, invasion and migration through modulating the Wnt/beta-catenin signaling pathway [90], or causing a reduction in telomerase activity, restoring the expression of methylation-silenced tumor suppressor genes and promoting Smac demethylation [87,95,96] to regulate key components of other signal pathways to inhibit the tumor cell growth, induce cell apoptosis and autophagy.