Data from in vitro studies indicate that anti-TG2 antibodies detected along the villous and crypt basement membranes in the jejunum from celiac disease patients may take part in the intestinal damage, particularly the remodeling of the small bowel mucosal architecture and the development of villous atrophy as well as crypt hyperplasia [43,45,46,47]. The gene discussed is TGM2; the disease is celiac disease.