We here found that LINC00473 was overexpressed in CRC tissues, which correlated with large tumor size and TNM stage, knockdown of LINC00473 inhibited the expressions of BCL-2, MRD gene and up-regulated the BAX for tumor killing, suggesting that LINC00473 was also an oncogene in the development of CRC. Here, BCL2 is linked to neoplasm.