GOLPH3 and malaria: Recently, a plant-based malaria vaccine candidate, Pfs25-CP VLP, which represents a chimeric non-enveloped VLP comprising Pfs25 fused to the Alfalfa mosaic virus coat protein (CP), has been engineered, transiently produced in Nicotiana benthamiana plants using a Tobacco mosaic virus (TMV)-based hybrid vector[31], purified and characterized [32].