RORA and neoplasm: Overall, we saw a significant increase in expression of transcription factors known to bind to the HOX-PBX and RFX3 sites on the 3q12.3 5′ LTR as well as a significant increase in those known to bind to the ATF and RORA sites on the 11p15.4 5′ LTR (Fig. 3b), implicating these sites and one or more of the upregulated factors in LTR activation during neoplasia.