This article focuses on the collection of OS-induced reproductive disease-related signaling pathways, including the p38 MAPK pathway, the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, the Jun N-terminal kinase (JNK) pathway, the forkhead transcription factors of the O class (FOXO) family, and apoptosis. Here, MAPK8 is linked to reproductive system disorder.