KLK3 and posterior cortical atrophy: Conversely, Misra-Hebert et al. [26] in their study conducted over 160,211 men aged ≥40 years with at least one visit to a primary care clinic during the years 2007–2014, reported higher rates of first prostate biopsy in men who were screened with a PSA test, especially for men with an increased risk of PCa (African Americans and men with positive family history).