Herein, we present the molecular genetic analysis of INF2 (using the HRM method and Sanger sequencing) performed on a large cohort of patients with FSGS/MCD (FSGS = 77 patients, MCD = 32 patients), as well as in a group of patients (6) characterized by a positive family history for ESRD in combination with advanced CKD/ESRD at the time of diagnosis. The gene discussed is INF2; the disease is chronic kidney disease.