It suggested that NPM overexpression was a potential independent predictor of poor prognosis in most solid tumors, including Ewing’s sarcoma, hepatocellular carcinoma, gastric cancer, ovarian serous cancer, colorectal carcinomas, glioma, astrocytoma, pancreatic adenocarcinoma and bladder carcinoma. The gene discussed is NPM1; the disease is colorectal carcinoma.