Angiotensin-converting enzyme inhibitors (ACEIs), which block the conversion of Ang I to Ang II, are widely prescribed and clinically beneficial.28, –30 ACE inhibition salvages the visual loss caused by diabetes.31 ACEI treatment of diabetic rats reduced VEGF gene expression and improved vascular permeability.32,33 However, there is no information on the effect of ACEI treatment of diabetic rats on the profile of retinal expression of both Ang II and Ang-(1-7). This evidence concerns the gene ACE and diabetes mellitus.