Single nucleotide variants (SNVs) in the leptin receptor gene (LEPR) and other genes in the leptin-melanocortin hypothalamic pathway (LEP, POMC-ADCY3, PCSK1, MC4R, BDNF) have been reported in humans with obesity-related traits, and in children specifically [6]. Here, LEPR is linked to obesity due to melanocortin 4 receptor deficiency.