ADRB2 and obesity due to melanocortin 4 receptor deficiency: Likewise, Martinez et al. [57] observed that women with the Gln27Glu polymorphism of the β2-adrenergic receptor gene (ADRB2) with higher CHO intake (>49% energy) showed a higher risk of obesity (OR = 2.56, p = 0.051) than those with lower CHO intake, although with borderline statistical significance.