Marti et al. (2006) [56] observed a higher risk between SNV pro12ala of the peroxisome proliferator-activated receptor gamma-gene (PPARy) and obesity (OR = 5.12, p < 0.04, 95% CI: 1.01–25.80) amongst individuals with higher CHO consumption (>49% energy). The gene discussed is ENSG00000279284; the disease is obesity due to melanocortin 4 receptor deficiency.