While mutations in genes encoding various types of proteins have been identified as causal for ALS, a number of the affected genes encode RBPs including TDP-43, FUS/TLS, and Heterogeneous nuclear ribonucleoprotein A1 and A2B1 (hnRNPA1 and hnRNPA2B1) (reviewed in [9]). Here, TARDBP is linked to amyotrophic lateral sclerosis.