LRP2 and chronic kidney disease: VD may also modulate oxidative stress and inflammation, reducing fibroblast activation and interstitial inflammation [74,75,77,109] Moreover, CKD progression and lower expression of megalin have been associated with lower 25(OH)-VD reuptake and therefore reducing intracrine 1,25(OH)2-VD production in the renal proximal tubules (Figure 2b) [50,51,110].