Out of exome variants with intermediate frequency (0.02 < SPBU MAF < 0.1) with high case-specificity score and statistical support, we found rs11863726 in HBQ1 and rs112984085 in VAV3 which were associated with T2D and obesity compared to controls, and rs685523 in ADAMTS13 as a specific marker for T2D. The gene discussed is ADAMTS13; the disease is obesity due to melanocortin 4 receptor deficiency.