In contrast, homozygous kinase-dead TRPM7R/R mice show normal platelet counts, size and morphology, thus suggesting that the lack of TRPM7 channel rather than its kinase activity accounts for the macrothrombocytopenia in Trpm7fl/fl-Pf4Cre mice [79]. Here, TRPM7 is linked to Macrothrombocytopenia.