To address whether defective intestinal colonization by CD4+ T cells lacking TRPM7 kinase activity could affect acute GVHD, the bone marrow (BM) of BALB/c WT mice was lethally irradiated and replaced by bone marrow (BM) cells from WT C57BL/6 mice together with WT or TRPM7R/R splenocytes. This evidence concerns the gene TRPM7 and graft versus host disease.