Mutation in the RAS oncogene-leading to constitutive signalling has been shown to induce the expression of CXCL8/IL8 in tumors [48] while others have shown that tumor intrinsic mutations in the β-catenin pathway modulates T-cell infiltration by silencing the expression of DC-recruiting chemokine CCL4 [89]. Here, CXCL8 is linked to neoplasm.