PIK3CA and endometrioid adenocarcinoma: Similarly, Dupreeuw et al. [33] tested the efficacy of NVP-BEZ235 (a dual pan-PI3K/mTOR inhibitor) and AZD6244 (an MEK1/2 inhibitor) in a PDX model harbouring a high-grade recurrent endometrioid carcinoma carrying PTEN, PIK3CA, and KRAS mutations.