KMT2A and acute leukemia: The 11q23.3 region is extremely prone to translocations, which cause the in-frame fusion of MLL with almost 100 partner genes [45] and generate fusion oncoproteins associated with acute leukemias, generally characterized by poor prognosis, with lymphoid or myeloid phenotype, or both, hence the name mixed lineage leukemia (MLL), commonly used to designate this gene.